Background: The liver is the location of various disorders, some of which become symptomatic and have clinical manifestations, while others stay quiet and can only be detected at autopsy. Histology is a distinct approach for determining acute and chronic hepatitis, steatosis, steatohepatitis, focal nodular hyperplasia, cirrhosis, cholestasis, hemangioma, and hepatocellular cancer. Steatosis is the most common histological change in liver tissue, followed by inflammation and fibrosis, according to research from multiple institutions. Objectives: To analyze the incidence of various liver illnesses in road traffic accident victims, which will provide us with data on the incidence in the general population of Orissa, as well as histological studies to detect steatosis, steatohepatitis, cirrhosis, hepatocellular carcinoma, and other disorders. The research will also look at the long-term impact of numerous toxins, infections, enzymatic changes, and metabolic storage problems on the liver. Results: Histopathological findings reveal most cases (35 out of 139) had portal fibrosis and inflammation. Fatty change/steatosis also accounts for the bulk of instances, 27 out of 139 (19.42%). Conclusion:Even though autopsies and histological studies of the liver are the best methods for determining undetected liver disorders, the autopsy rate has lately declined. To increase the number of autopsies, doctors and pathologists should take an active role and persuade families to consent to autopsies in situations of organ failure.