European Journal of Cardiovascular Medicine

Background: In general anaesthesia, hemodynamic alterations during endotracheal intubation are a key issue. This study evaluated the effectiveness of intravenous and intranasal dexmedetomidine (DEX) in reducing the stress response following larynogoscopy and endotracheal intubation. Material and Method: The study involved 90 persons who were split into two groups: Group DIN (n = 45) and Group DIV (n = 45) in a prospective, randomised, double-blind approach. The DIV group was administered a 0.5 mcg/kg intravenous infusion of dexmedetomidine (DEX) during a 40-minute period, whereas the DIN group got a 1 mcg/kg intranasal injection of DEX 40 minutes before to induction. The main goal was to compare the mean arterial pressure (MAP) between the two groups starting 40 minutes before induction and every 10 minutes until anaesthesia was induced at the moment of intubation. following that, every 1 minute interval was continued until 5 minutes, at 7 and 10 minutes following intubation. Comparisons of heart rate, systolic and diastolic blood pressure, sedation, and other side effects were the secondary outcomes. Statistica 6.0 and Graph Pad Prism version 5 were used for the statistical analysis. Result: During the trial period, all haemodynamic parameters in both groups remained within 20 percent of their baseline levels. P > 0.05 indicated that there was no statistically significant difference in MAP between the two groups. The DIV group had a substantially greater preoperative sedation score than the DIN group (P = 0.014). Conclusion: The hemodynamic stress reactions to laryngoscopy and endotracheal intubation can also be reduced by intranasal DEX, similar to IV DEX, without appreciably altering the mean arterial pressure (MAP) between the two groups.