European Journal of Cardiovascular Medicine

Background:  The pharmacotherapy of asthma is a complex and evolving topic. A detailed understanding of the pathophysiologic processes involved in the asthmatic response forms the basis for understanding the actions of drugs used to treat this condition.Materials and methods: Retrospective analysis was performed on medical records of 96 children with acute bronchial asthma, including 42 children treated with aminophylline (control group) and 54 children with doxofylline (observation group). The therapeutic effects, complication and recurrence rates of the two groups were observed after 7 days of treatment. At the same time, the duration of related symptoms and changes of pulmonary function indicators as well as blood gas analysis indicators before and after treatment in the two groups were compared.Result: Out of 90 patients, most of the pediatric patients suffering from asthma 45.6% were found in the age group of 5-8 years followed by (41.1%) 1-4 years and the last one is 9-13 years (13.3%). Demographic analysis of data revealed that there were 65.4% male and 34.4% female in the study. Out of 90 Paediatric asthma patients, 30% were suffering from mild persistent and the remaining 63.3% were patients of moderate persistent and 6.7% are least one of severe asthma. The percentages of the patients who were 61.1% treated with a single anti-asthmatic drug (monotherapy) excluding other concomitant medications used together.Conclusion: Doxofylline is of better efficacy in pediatric bronchial asthma, which could more effectively shorten the duration of symptoms, improve the lung function and blood gas function, reduce the incidence of complications and recurrence, thereby being worthy of clinical application.