European Journal of Cardiovascular Medicine

Several emerging evidences have documented cardiovascular disease arise due to multifactorial causes with elevated diagnostic serum levels such as Lactate dehydrogenase (LDH).  LDH could be a useful marker of systemic inflammation, as it is a cytoplasmic enzyme that is widely expressed in tissues. As elevated LDH levels reflect cardiac damage and is used to diagnose acute myocardial infarction, valve heart disease, heart failure, and coronary heart disease, therefore, present study was aimed to evaluate the serum LDH levels in the pathogenesis of CAD. Present study was carried out at Manva kheda, Udaipur, Rajasthan, from 2013 to 2014on 100 patients suffering from myocardial infarction and for comparative study 50 controls were included after check-up at our hospital and after explaining about the examination, a signed informed consent was obtained. So from all the participants 5ml of blood was obtained and serum was extracted for further LDH analysis. It was observed that, total mean age of controls and patients is 54.64 ± 7.75 and 57.36 ± 11.96 years respectively. LDH level was 157.74 ± 23.11. Males had 158.08 ± 23.37 and females had 156.40 ± 23.16 U/L. With biochemical parameters done on MI Patients, the value of LDH was 317.25+36.91 U/L. The males had 316.71+41.53 and females had 318.88+17.21. The t and p value of patients (male) and control (male) was statistically highly significant with 26.20; P<0.001 and t and p value of patients (female) and control (female) was also statistically highly significant 20.08; P<0.001.Hence, concluded that, LDH in myocardial infarction revealed increased serum levels for all patients with myocardial infarction and remained to be a significant marker in predicting MI.