European Journal of Cardiovascular Medicine

Introduction: Kidney disease is defined as an abnormality of kidney structure or function with implications for the health of an individual, which can occur abruptly, and either resolve or become chronic. Chronic kidney disease (CKD) is a general term for heterogeneous disorders affecting kidney structure and function with variable clinical presentation, in part related to cause, severity, and the rate of progression. Aims: To study carotid intimal thickness in different stages of chronic kidney disease. To study the correlation between the carotid artery intimal-medial thickness with lipid profile in Chronic Kidney disease. Materials and Methods: The present study was a cross sectional single centre, observational study. This Study was conducted from Jan 2015 to August 2016 at Department of Medicine of a tertiary care hospital. Result: There was negative correlation of CIMT with eGFR on both sides but statistical significance was not reached. There was no significant correlation with creatinine levels. That majority cases had serum creatinine above 4 mg/dL. Raised and normal CIMT were evident in nearly equal proportions in both right (p=0.839) and left (p=0.939) carotids.  That there was no association of raised CIMT with CKD stage in either right (p=0.932) or left (p=0.886). Association of CIMT with patient management. Patients who were managed by hemodialysis had raised CIMT in higher number of patients (63% on right and 56.4% on left) than those managed conservatively (37% on right and 43.6% on, left).  Conclusion: Raised CIMT is substantially linked with lipid markers in CKD patients. No correlation between elevated CIMT and either CKD stage or renal function measures was found, indicating that CKD stage has little to no effect on elevated CIMT. The CIMT of patients receiving haemodialysis, however, was elevated, indicating a higher risk in this population than in patients receiving conservative therapy.