European Journal of Cardiovascular Medicine

Volume 5 Issue :4

2015

Research Article Open Access

Investigating Serum Prolactin Levels in Metabolic Syndrome and Their Association with Insulin Resistance

Divya C

Pages 26 - 30

Abstract

Objective: To explore the association between serum prolactin levels and insulin resistance markers in metabolic syndrome patients, providing potential insights for targeted therapeutic interventions. Methodology: Through the use of a cross-sectional methodology, the purpose of this study was to investigate the possibility of a connection between insulin resistance and blood prolactin levels. Participants in this study were comprised of adults who had been diagnosed with metabolic syndrome. Individuals were recruited from the outpatient clinics of the nearby hospitals. People ranging in age from thirty to sixty years old were included in the study. There was a significant age gap between them. Serum prolactin levels, insulin resistance indicators (such as the HOMA-IR), and fasting glucose levels were some of the studied metabolic markers. Other metabolic markers included lipid profiles. Specific metabolic markers, such as those listed below, were among those that were investigated. Result: The findings indicate that there is a significant positive link between the levels of serum prolactin and insulin resistance measures such as HOMA-IR, fasting glucose, and triglyceride levels. The findings indicate that there is an inverse relationship between the levels of prolactin and HDL cholesterol. Because greater prolactin levels were also related with obesity and inflammatory markers, it is probable that they contribute to the worsening of metabolic dysregulation. This is because of the presence of both factors. Based on these findings, it seems that elevated levels of prolactin in the blood may be a significant endocrine component that contributes to insulin resistance in metabolic syndrome. Conclusion: Patients with metabolic syndrome who have increased prolactin levels also have insulin resistance, according to the findings of this research, which give significant support to this assertion. As a result of its impact on inflammation, lipid metabolism, and obesity, prolactin may have a substantial role in the development of metabolic syndrome. It is necessary to do further research, especially longitudinal studies, to understand the nature of this connection better and ascertain whether prolactin might be an effective therapeutic target for treating insulin resistance in metabolic syndrome.

Research Article Open Access

An Observational Study on Chronic Epididymo-orchitis

Pages 21 - 25

Abstract

Background: Epididymoorchitis, a prevalent inflammatory condition that impacts both the epididymis and the testis, served as the basis for the current study. The primary aim of this investigation was to shed light on the various factors involved in the development of chronic epididymoorchitis. Methods: This prospective observational research involved a group of 50 patients who had been diagnosed with chronic epididymoorchitis. We designed a structured questionnaire and collected data systematically. The patients underwent comprehensive examinations, received accurate diagnoses, and were provided with suitable treatment. The gathered data were then analyzed utilizing SPSS version 20. Results: The most common age range for the occurrence of epididymo-orchitis is typically between 31 and 40 years. Among the cases, industrial workers accounted for a significant portion, with 15 individuals, representing 30% of the total cases. Pain served as the predominant clinical symptom, being present in all 50 patients, which constituted 100% of the total cases. Urinary tract infection (UTI) emerged as a relatively common predisposing factor, observed in 12 cases, making up 24% of the total cases. Staphylococcus aureus (S. aureus) was the most frequently encountered organism in urine cultures among the isolated organisms. Medical treatment was the chosen approach for managing the majority of cases, with 36 patients, equivalent to 72% of the total, undergoing this form of treatment. Conclusion: Finding a positive urine culture in 62% of cases could suggest an underlying genitourinary issue. Staphylococcus aureus (S. aureus) was the most commonly identified organism in urine cultures among those isolated. Notably, in our research, a substantial proportion of patients responded positively to empirically administered treatment.

Research Article Open Access

Takayasu Arteritis with Recurrent Acute Limb Ischemia

Pages 11 - 20

Abstract

Takayasu arteritis (TA) is a rare, systemic; large- vessel vasculitis that usually involves women of child-bearing age, causing severe vascular extremity ischemia that may necessitate revascularization. We report a case of 29-year- old female, who presented with sudden right leg pain, accompanied by paresthesia, poikilothermia, pallor, and pulselessness of the lower extremities. There was a past history of ischemic stroke at the age of 25 years and one-year history of bilateral leg claudication. Computed tomographic angiography revealed thrombus in the infrarenal abdominal aorta with segmental occlusion of the right mid- to distal external iliac artery, complete occlusion of the right common femoral artery with distal collateral blood flow from the right inferior

Research Article Open Access

Factors Participating in Readmission of Heart Failure Patient, and Hospital Burden in Karachi, Pakistan

Pages 1 - 10

Abstract

Background: Heart failure (HF) is one of the leading causes of hospitalization and readmission among older adults. Chronic heart failure (CHF) is the most common cause of readmission among patients in Pakistan and worldwide. Despite this recent attention to HF readmission, we knowrelatively little about its actual causes despite the fact that patients themselves can identify the underlying factors that contribute to their readmissions.

European Journal of Cardiovascular Medicine

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