European Journal of Cardiovascular Medicine

Volume 7 Issue :2

2017

Research Article Open Access

Comparative Study of Dexmedetomidine and Propofol for Sedation in Pediatric Patients Undergoing MRI Scans.

Navdeep Singh Dhaliwal

Pages 17 - 19

Abstract

Sedation is often required for pediatric patients undergoing MRI scans to ensure immobility and image quality. Dexmedetomidine and propofol are commonly used sedatives, but their comparative efficacy and safety profiles in children remain a topic of debate. Objective: To compare the efficacy, safety, and recovery profiles of dexmedetomidine and propofol for sedation in pediatric patients undergoing MRI scans. Methods: A prospective, randomized controlled trial was conducted with 100 pediatric patients aged 1–12 years. Patients were randomized to receive either dexmedetomidine or propofol. Primary outcomes included sedation success rate, recovery time, and incidence of adverse events. Results: Dexmedetomidine showed a comparable sedation success rate to propofol (94% vs. 96%, p=0.65). Recovery time was significantly longer with dexmedetomidine (25.3 ± 6.2 minutes) compared to propofol (12.8 ± 4.5 minutes, p<0.001). Adverse events, including hypotension and bradycardia, were more frequent with dexmedetomidine (18% vs. 8%, p=0.04). Conclusion: Both dexmedetomidine and propofol are effective for pediatric MRI sedation, but propofol offers faster recovery and fewer adverse events. Dexmedetomidine may be preferred in specific cases where respiratory depression is a concern

Research Article Open Access

A Study on correlation between serum cortisol and severity of acute ischemic stroke

Sarada Vempaty,

Sravan Reddy V

Pages 11 - 16

Abstract

Background: The stress response that occurs after the event of acute stroke causes the activation of the hypothalamo–pituitary–adrenal (HPA) axis. Certain studies have found that increased serum cortisol level in patients with acute stroke is related to larger infarct volume, greater stroke severity and poor outcome, including death. Materials and methods: All patients were included in the study who was admitted within 6 hours in the hospital after the episode of stroke. Scandinavian Stroke Scale (SSS)ii was monitored in all patients from admission. SSS was performed every 2 hours in the first 24 hours, every 4 hours in the next 48 hours and then daily up to day 7. Blood samples were obtained for routine investigation and estimation of serum cortisol. No patients had blood samples drawn for cortisol determination between 01:00 and 07:00 am. Result: 50% of the group is male and 50% are female, with an average age range of 50 to 59. The cortisol level was 637 nmol/L on average. Acute ischemic stroke affected 78 out of the 90 patients, while acute hemorrhagic stroke affected 12. The average time was 11.53 hours, and the average SSS score was 22.90. The SSS and serum cortisol correlation coefficient was -0.990, showing a significant link. High serum cortisol levels were associated with lower SSS scores, and the p-value was < 0.001, indicating statistical significance. Conclusion: A stress response causing an increase in serum cortisol occurs in AIS. This response is detrimental to the patient. The serum cortisol at baseline can be considered a marker of severity, short- and long-term prognosis, and mortality after AIS.

Research Article Open Access

Advances in Dental Technologies Aids Patients in Improving Quality of Life

Pages 1 - 10

Abstract

ackground: Once in a while, new innovations emerge in the world of restorative dentistry. The emergence of new bonding agents, dental liners and bases, and adaptive capabilities of components offer new opportunities. Dental liner materials have improved tremendously over the last few years. They are applied in a thin layer to seal the walls of the cavity or minimize the influx of bacteria following restorative procedures. On the other hand, dental bases are applied in thick layers and support a restorative material during the placement as well as function. The dental liners and bases are widely used to improve the outcome of dental caries treatment and several dental restoration procedures. Apart from this, dental technology has improved a lot over the last few years and will continue to advance the field and benefit patients and healthcare professionals alike. While Covid-19 presented various uncertainties during the pandemic, it is safe to say that the pandemic increased patient awareness about safety measures and sanitation, which will boost the demand for dental technologies. Here are some of the dental technologies which will be a big hit in the coming years.

European Journal of Cardiovascular Medicine

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