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Background: Fractures, stemming from trauma or medical conditions, pose significant challenges to global healthcare. Despite extensive research on biomechanical aspects, the systemic impact on mineral homeostasis, particularly urinary calcium dynamics, remains understudied in adults undergoing fractures and surgical interventions. Materials and Methods: A prospective observational study conducted at a tertiary medical college in Uttar Pradesh, India, aimed to scrutinize urinary calcium levels in adults with fractures and surgical intervention compared to a fracture-free control group. Participants included adult patients (n=150/group) with fractures requiring surgical intervention and age-matched controls. Serum and urinary calcium levels were assessed, and statistical analyses were performed using appropriate tests. Results: The "Fracture + Surgery" group exhibited lower mean serum calcium levels (9.3 mg/dL) compared to controls (9.7 mg/dL, p<0.001). Urinary calcium levels were significantly elevated in the "Fracture + Surgery" group (175 mg/24h) compared to controls (120 mg/24h, p<0.001). Subgroup analysis based on fracture types revealed nuanced variations in urinary calcium dynamics. Type 2 fractures exhibited the highest mean urinary calcium levels (180 mg/24h, p<0.001). Conclusion: Our study highlights disruptions in calcium metabolism following fractures and surgical interventions, emphasizing the need for comprehensive clinical management. The setting in Uttar Pradesh provides unique insights into diverse patient populations. Future research should explore molecular mechanisms underlying these changes and targeted interventions.
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