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Research Article | Volume 13 Issue 12 (Dec, 2023) | Pages 128 - 133
A Prospective Study of Interindividual Variation in Effect of Radiotherapy on Bladder and Rectal Toxicity in Prone and Supine Position
1
Visiting Physician, MBBS, MD, Visiting Consultant Radiation Oncology at Netaji Subhash Chandra Bose Cancer Hospital, Kolkata, West Bengal 700094 Visiting Physician, MBBS,Diploma in Child Health, Attached With Suraksha Diagnostics,Jadavpur, Kolkata, and West Bengal 700040
Under a Creative Commons license
Open Access
Received
Oct. 1, 2023
Revised
Nov. 7, 2023
Accepted
Dec. 1, 2023
Published
Dec. 20, 2023
Abstract

Introduction: The most common cancer among women in the last 20 years has been cervical cancer. In India, the age range of 55 to 59 is when the incidence of cervical cancer peaks.Every eight minutes, a woman in India loses her life to cervical cancer. Concurrent chemotherapy and radical radiation therapy are the accepted standards of care for advanced cervical carcinoma.Combining teletherapy and brachytherapy is a common practice.One form of teletherapy is whole-pelvic radiotherapy, which uses external beam therapy to treat the primary tumor and then uses brachytherapy and regional lymphatics to increase the gross tumor in the cervix. However, in the event that this treatment is successful, there is a possibility that the bladder, rectum, and small intestine will inadvertently be exposed to normal tissue radiation. Aims:The purpose of this study is to determine whether less toxicity results from lowering the dose in small bowl, prone-positioned urine bladders during pelvic radiotherapy. Materials and methods: Prospective randomizedly allocated control study from January 2017 to January 2018 Patients visiting at Radiotherapy department Out door of Nilratan Sirkar Medical College and Hospital,Kolkata-700014. Result:V20, V30, and V40 for the urinary bladder (UB) did not significantly differ between the two positions, according to our findings (p > 0.05). However, UB V45 demonstrated a notable difference (p = 0.9), while UB V50.4 indicated a statistically significant variance (p = 0.021), indicating higher radiation exposure in the supine position. UB Dmean and total volume did not exhibit substantial differences (p > 0.05) and Regarding the rectum, V20, V30, V40, and V45 showed no significant variation between positions (p > 0.05). However, rectum V50.4 indicated a significant difference (p = 0.004), implying higher radiation exposure in the prone position. Rectum Dmean and total volume did not display substantial differences (p > 0.05). Conclusion:In conclusion, our study revealed varied radiation exposure in prone versus supine positions. The urinary bladder indicated higher exposure in supine (V50.4 p = 0.021), while the rectum exhibited increased exposure in prone (V50.4 p = 0.004). Overall, patient positioning significantly influences organ-specific radiation doses.

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