Alleviate COPD using Liquorice and Asafoetidaenriched foods by combating AGE-RAGE axis

doi:10.5083/ejcm/2023

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Review Article | Volume 13 Issue:3 (, 2023) | Pages 1482 - 1495

Alleviate COPD using Liquorice and Asafoetidaenriched foods by combating AGE-RAGE axis

Under a Creative Commons license

Open Access

DOI : 10.5083/ejcm/2023

Received

July 8, 2023

Revised

July 21, 2023

Accepted

Aug. 28, 2023

Published

Aug. 31, 2023

Abstract

Advanced Glycation End Products (AGEs) are formed in the lungs either spontaneously or as a result of the insult due to cigarette smokes. These AGEs have deleterious effects due to their pro oxidant and inflammatory actions. The AGEs can interact with the receptor for AGE, called RAGE, triggering various kinase pathways that activate transcription factor NF-κB (nuclear factor kappa B). This, in turn, leads to the production of several inflammatory substances and promoters. Impeding the formation of AGEs and inhibiting the AGE-RAGE axis can prove beneficial in down regulating the inflammatory process, leading to favourable outcomes. Asafoetida and liquorice are two such herbs that can significantly impede the AGE-RAGE-NF-κBaxis, which plays a key role in the pathogenesis of chronic obstructive pulmonary disease (COPD). These herbs have the potential to improve symptoms and lung function in patients suffering from this condition.

Keywords

Licorice in COPD

Asafetida

AGE inhibition

Herbs in COPD

Herbal RAGE blockade

Smoking and COPD

European Journal of Cardiovascular Medicine

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