European Journal of Cardiovascular Medicine

Background and Objectives: Chronic rhinosinusitis (CRS), a prevalent ENT condition, often presents treatment-resistant cases. Gastroesophageal Reflux Disease (GERD) causing Laryngopharyngeal reflux (LPR) is implicated in its etiology. This study aims to assess LPR prevalence in refractory CRS and the impact of combining proton pump inhibitors (PPIs) with functional endoscopic sinus surgery (FESS). Methods: 50 refractory CRS patients were evaluated, split into study (PPIs + FESS) and control (FESS only) groups in the Department of ENT at a tertiary care medical college in India. CRS indicators were assessed, and post-surgery, study patients received intranasal steroids and PPIs. A 3-month follow-up tracked symptom relief. Result: Majority of refractory CRS patients had LPR, mainly affecting the posterior larynx. Nasal obstruction, discharge, and polyps were common CRS indicators. Study group with PPIs showed greater improvement in symptoms, notably by the third postoperative month. Conclusion: The study highlights a significant link between refractory CRS and GERD. PPIs, when used alongside FESS, offer effective refractory CRS management, emphasizing combined treatment's advantages.