European Journal of Cardiovascular Medicine

Background and Aim: Dyslipidemia is thought to confer risk of cardiovascular disease development. Overt hypothyroidism is associated with lipid abnormalities. As SCH is being diagnosed more frequently in young and middle-aged people, there is a need to know the effect of SCH on cardiovascular risk factors in young in tertiary centre in Gujarat, India. Therefore, the objective of this study is to analyze the relation between SCH and serum lipid parameters in this subgroup. Material and Methods: This observational study was conducted at Department of Medicine at Tertiary Care Institute of Gujarat, India in subjects diagnosed with Sub Clinical Hypothyroidism. Blood samples were drawn at early morning after an overnight fast in a sterile bottle. Serum was separated for the estimation of serum TSH, T3, T4, and total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), which were derived from TC and TG, using Friedwald's Formula [LDL = TC - (HDL + TG/5)], Very low-density lipoprotein (VLDL) derived from TG.. Lipid profile was compared with matched controls. Results: The levels of TSH are significantly higher in group II compared to group I, which is statistically significant. (p≤0.05) There is a significant increase in the serum TC level in group II individuals when compared to group I, which is statistically significant. (p≤0.05). There is also a significant increase in serum LDL Cholesterol in group II individuals when compared to group I individuals, which is statistically significant. Conclusion: Subclinical hypothyroidism (SCH) is associated with increased serum TC and LDL-C levels. Therefore, there is a potential association between subclinical hypothyroidism and atherosclerosis. Larger studies are needed to prove this association in Patients.