Contents
Download PDF
pdf Download XML
284 Views
93 Downloads
Share this article
Research Article | Volume 13 Issue:4 (, 2023) | Pages 1418 - 1425
Association of serum Vitamin– D levels with Chronic Obstructive Pulmonary disease
1
1Assistant professor- Department of TB and chest MGM Medical College and LSK Hoapital Kishanganj.
Under a Creative Commons license
Open Access
Received
Nov. 2, 2023
Revised
Nov. 28, 2023
Accepted
Dec. 5, 2023
Published
Dec. 22, 2023
Abstract

Role of Vitamin D for intestinal absorption of calcium is well known. Deficiency causes musculoskeletal conditions osteoporosis and rickets. The involvement of Vitamin- D in the immune reaction is well established as it facilitates enhancement and regulation of immune mechanisms both innate and acquired in various tissues including lung. Its activation has potent antiproliferative, pro-differentiative and immunomodulatory functions. These properties of Vitamin D got attention in recent years with regards to chronic diseases like COPD and other lung pathology. Present study aim to correlate vitamin D and COPD. Objectives: 1-To estimate serum vitamin D level in COPD (Chronic Obstructive Pulmonary Disease) patients and compare it with controls (normal healthy adults). 2. To compare serum vitamin D level with severity of COPD in these patients. Material and method: Single-center randomized cross-sectional study done at a tertiary care centre which includes 100 Patients of aged between 40-60 years with diagnosis of COPD on the basis of clinical and radiological sign and symptoms with Spirometric criteria (FEV1/FVC - <0.7, % FEV1 <80%). COPD patient further categorized into GOLD grade 1,2,3 and 4 on the basis of severity and compared there vitamin- D levels separately and tried to correlate it with severity of disease.103 Controls were taken includes healthy subjects of age 40-60 years. Interventions: We measured total serum 25-(OH)-D by Diasorin competitive radioimmunoassay (RIA) (AID Diagnostika, GmbH, Strasburg, Germany) at study centre. Results: The mean Serum Vitamin 25-(OH) D of COPD patients was 19.4 ± 7.9 ng/ml, Among controls it was 30.5 ± 8.6 ng/mL.( p <0.05). On the basis of severity of COPD, serum levels of Vit D are, 31.30 ± 11.69, 18.56 ± 5.36, 18.79 ± 6.81 and 16.82 ± 7.30 ng/md in COPD grade 1,2,3 and 4 respectively with p<0.05. Conclusions: Low Vitamin D was highly prevalent among COPD as compared to general population in same geographical area and Vitamin- D insufficiency increases with progression of COPD.

Keywords
Recommended Articles
Research Article
Study The Effects of Dexmedetomidine on Postoperative Nausea and Vomiting. And Adverse Effects Like Bradycardia and Hypotension In Patients Undergoing Laparoscopic Surgeries
...
Published: 30/01/2025
Download PDF
Research Article
Study the hemodynamic parameters of Dexmedetomidine and Tramadol
...
Published: 30/09/2025
Download PDF
Research Article
Study the efficacy of dexmedetomidine for attenuation of hemodynamic responses in patients undergoing laparoscopic surgeries
...
Published: 30/12/2024
Download PDF
Research Article
Compare The Postoperative Analgesia and Adverse Effects of Bupivacaine in Comparison to Bupivacaine and Nalbuphine Combination During Spinal Anesthesia in Lower Abdominal Surgeries
...
Published: 30/09/2025
Download PDF
Chat on WhatsApp
Copyright © EJCM Publisher. All Rights Reserved.