Introduction: The consequences of CSOM varies from hearing loss, persistent otorrhoea, mastoditis, labrynthitis, facial palsy and also leads to dangerous complications such as intracranial abscess and thrombosis. Chronic suppurative otitis media (CSOM) is persistent inflammation of the middle ear or mastoid cavity. The treatment of CSOM is also controversial as the microbiotia and susceptibility patterns keep changing from time to time and vary from region to region. So here we tried to project a data of cross sectional study which gives the epidemiology of CSOM and its microbiological study. Materials and Methods: This is a cross sectional study on CSOM Patients from whom clinical details were collected. All pus swabs were collected under aseptic precautions and processed for gram stain, culture, biochemical reactions and sensitivity testing as per recommendations. All the data entered in to Spread excel sheet for analysis. All descriptive quantitative variables were expressed as numbers and percentages. Results: Unilateral CSOM is the most common complaint observed i.e, 63.1%. On audiometric examination 64.8% of patients had <40dB of hearing loss and the majority CSOM patients had conductive hearing loss (69.7%). Predominant pathogen isolated was Pseudomonas aeruginosa (33%) followed by Klebsiella pneumoniae (22%) and Staphylococcus aureus (19%). Pseudomonas aeruginosa which were isolated showed 96.9% susceptibility to amikacin, 81.8% to levofloxacin, 81.8% to Ceftazidime-clavulanic acid, 81.8% to piperacillin+tazobactum, 75.7% to ceftazidime, and 87.8% sensitive to meropenem. Conclusion: Complications of CSOM can be prevented by appropriate antibiotic usage according to the microbiological report, irrational use of antibiotics cause the increase in multidrug resistant pathogens so it is strongly recommended to test for microbiological culture and sensitivity prior to usage of antibiotics. Early microbiological ensues prompt and effective treatment to avoid such complications.