European Journal of Cardiovascular Medicine

Background: This study was conducted to correlate, inflammatory markers with mechanical ventilation and mortality in Covid- 19 patients, IL-6 levels with mechanical ventilation and mortality in Covid-19, and CRP levels with mechanical ventilation and mortality in Covid- 19. Methods: This was a hospital-based descriptive cross-sectional study conducted among 200 cases, considering a 13-point difference in the IL-6 or CRP levels among the patients who needed mechanical ventilation, at the Department of Medicine, Tertiary Care Hospital, Mumbai, over a period of three years, after obtaining clearance from the institutional ethics committee and written informed consent from the study participants. Results: The CRP levels were significantly higher among the patients with mechanical ventilation when compared to the patients who were not ventilated [103.22 ± 99.04 mg/dl (present) vs. 78.70 ± 75.90 mg/dl (absent) mg/dl]. The IL-6 levels were significantly higher among the patients with mechanical ventilation when   compared to the patients who were not ventilated [432.09 ± 509.95 IU/L (present) vs. 81.79 ± 195.44 IU/L (absent) mg/dl]. The CRP levels were significantly higher among the patients who died when compared to the patients who were alive [137.49 ± 117.35 mg/dl (dead) vs. 74.73 ± 70.61 mg/dl (alive)]. The IL-6 levels were significantly higher among the patients who died when compared to the patients who were alive [491.95 ± 541.59 IU/l (dead) vs. 69.70 ± 156.54 IU/l (alive)]. Conclusion: CRP acts as a fair predictor for mortality in the present study, implying that elevated CRP levels may indicate an increased mortality risk.