Introduction: Cranioplasty is a critical neurosurgical procedure performed after decompressive craniectomy (DC) to restore skull integrity and improve neurological function. The optimal timing of cranioplasty—early (<3 months) versus late (>3 months)—remains a subject of clinical debate due to potential implications on surgical complexity, complications, and neurological recovery. Objective: To evaluate the impact of timing of cranioplasty on intraoperative blood loss, operative time, postoperative recovery, and neurological outcomes. Methods: This prospective, comparative study was conducted at G. R. Medical College and J.A. Group of Hospitals, Gwalior, from January 2020 to June 2021. A total of 30 patients undergoing cranioplasty were enrolled and divided equally into early (n=15) and late (n=15) cranioplasty groups. Intraoperative parameters (blood loss, operative time), hospital stay, complications, and neurological outcomes (GCS, GOS, MMSE, Barthel Index) were recorded and analyzed at admission and 3-month follow-up. Results: Early cranioplasty was associated with significantly lower blood loss (209.33 ± 33.48 mL vs. 346.67 ± 44.51 mL, p<0.05), shorter operative time (1.23 ± 0.26 hrs vs. 2.07 ± 0.65 hrs, p<0.05), and reduced hospital stay (8.67 ± 2.94 days vs. 12.07 ± 3.10 days, p<0.05). Although improvements in neurological scores were observed in both groups, early cranioplasty showed better trends across all functional scales, albeit without statistical significance. Dural tear incidence was higher in the late group (33.3% vs. 6.7%). Conclusion: Early cranioplasty is associated with favorable intraoperative and postoperative outcomes, including reduced surgical time, blood loss, and complication rates. While neurological recovery was comparable, early intervention showed a trend toward better functional outcomes. Early cranioplasty may be considered safe and beneficial in clinically stable patients without active infection or cerebral edema.
Cranioplasty is a neurosurgical procedure aimed at restoring the contour, integrity, and protective function of the skull following decompressive craniectomy (DC), a life-saving intervention often required for patients with raised intracranial pressure secondary to traumatic brain injury (TBI), malignant middle cerebral artery (MCA) infarctions, subdural hematomas (SDH), or intracerebral hemorrhage (ICH) [1,2]. The indications for decompressive craniectomy have expanded significantly, with DC being widely adopted for refractory intracranial hypertension management [3].
While cranioplasty is considered a secondary reconstructive step, it holds substantial therapeutic significance. Beyond cosmetic restoration, it contributes to improved cerebral hemodynamics, cerebrospinal fluid (CSF) dynamics, metabolic regulation, and neurological recovery [4–6]. However, the optimal timing of cranioplasty remains a subject of ongoing debate. Early cranioplasty (typically within 3 months of DC) may facilitate earlier neurological rehabilitation and reduce complication rates such as hydrocephalus and syndrome of the trephined [7–9]. Conversely, delayed or late cranioplasty (beyond 3 months) is often preferred in cases with infection risk, poor wound healing, or unresolved cerebral edema, though it may be associated with prolonged operative time, increased blood loss, and suboptimal cognitive recovery [10,11].
Several studies have attempted to elucidate the effect of cranioplasty timing on outcomes such as operative time, intraoperative blood loss, postoperative complications, and functional neurological improvement [12,13]. Nonetheless, findings have been inconsistent, and most studies have lacked uniform criteria for defining “early” versus “late” intervention. Furthermore, standardized tools for assessing neurological outcomes—such as the Glasgow Coma Scale (GCS), Glasgow Outcome Scale (GOS), Mini-Mental State Examination (MMSE), and Barthel Index (BI)—have not been consistently applied across studies [14].
This prospective comparative study aims to evaluate the impact of timing of cranioplasty (early vs. late) on key intraoperative parameters (blood loss, operative time), postoperative recovery (hospital stay, complications), and neurological function, using validated assessment tools. The goal is to provide evidence-based guidance on the ideal timing of cranioplasty to optimize both surgical and neurological outcomes.
This was a prospective, comparative, single-institutional study conducted between January 2020 and June 2021 in the Department of Neurosurgery at G. R. Medical College and J.A. Group of Hospitals, Gwalior (Madhya Pradesh), India, a recognized tertiary care center. The study was approved by the Institutional Ethics Committee, and written informed consent was obtained from all participants prior to enrollment.
A total of 30 patients undergoing cranioplasty were included in the study. These were equally divided into two groups:
Patients with craniectomy defects secondary to raised intracranial pressure due to conditions such as:
Demographic and clinical data were collected, including:
All patients were followed up for 3 months to evaluate neurological recovery and detect complications such as hydrocephalus, seizures, subdural hematoma, or delayed infection.
Standard surgical technique was followed for all patients:
Autologous bone flap (preserved in the abdominal subcutaneous layer)
Methyl methacrylate
Titanium mesh
In cases with persistent cerebral herniation, intraoperative CSF drainage or ventriculoperitoneal shunt placement was considered. Implants were fixed using titanium plates and screws. Subgaleal drains were placed in all cases.
Data were analyzed using SPSS version 20.0. A p-value < 0.05 was considered statistically significant.
Table 1: Gender-wise Distribution of Patients
Gender |
Early Cranioplasty |
Late Cranioplasty |
Male |
6 (40.0%) |
15 (100.0%) |
Female |
9 (60.0%) |
0 (0.0%) |
Observation: Male predominance, particularly in the late cranioplasty group, reflects higher risk of traumatic injuries among males due to increased involvement in outdoor and vehicular activities.
Table 2: Age Distribution
Parameter |
Early Cranioplasty |
Late Cranioplasty |
Mean ± SD |
35.73 ± 11.13 yrs |
32 ± 9.56 yrs |
Median |
35 yrs |
28 yrs |
Table 3: Age Group Distribution
Age Group (Years) |
Early (n=15) |
% |
Late (n=15) |
% |
< 20 |
2 |
13.3% |
1 |
6.7% |
21–30 |
2 |
13.3% |
8 |
53.3% |
31–40 |
7 |
46.7% |
3 |
20.0% |
41–50 |
2 |
13.3% |
2 |
13.3% |
51–60 |
2 |
13.3% |
1 |
6.7% |
Table 4: Indications for Decompressive Craniectomy
Indication |
Early (n=15) |
% |
Late (n=15) |
% |
Head Injury |
12 |
80.0% |
12 |
80.0% |
MCA Infarct |
3 |
20.0% |
2 |
13.3% |
Basal Ganglion Bleed |
0 |
0.0% |
1 |
6.7% |
Table 5: Material Used for Cranioplasty
Material Type |
Early |
% |
Late |
% |
Autologous Bone Graft |
8 |
53.3% |
5 |
33.3% |
Bone Cement |
4 |
26.7% |
7 |
46.7% |
Titanium Mesh |
3 |
20.0% |
3 |
20.0% |
Table 6: Dural Tear Incidence
Dural Tear |
Early |
% |
Late |
% |
No |
14 |
93.3% |
10 |
66.7% |
Yes |
1 |
6.7% |
5 |
33.3% |
Table 7: Operative Time
Operative Time (hrs) |
Early |
% |
Late |
% |
0–1.0 |
8 |
53.3% |
3 |
20.0% |
1.1–1.5 |
7 |
46.7% |
1 |
6.7% |
1.6–2.0 |
0 |
0.0% |
3 |
20.0% |
2.1–2.5 |
0 |
0.0% |
7 |
46.7% |
2.6–3.0 |
0 |
0.0% |
1 |
6.7% |
Group |
Mean Operative Time (hrs) |
|||
Early Cranioplasty |
1.23 ± 0.26 |
|||
Late Cranioplasty |
2.07 ± 0.65 |
Table 8: Hospital Stay
Duration (days) |
Early |
% |
Late |
% |
1–5 |
1 |
6.7% |
0 |
0.0% |
6–10 |
12 |
80.0% |
6 |
40.0% |
11–15 |
1 |
6.7% |
6 |
40.0% |
>15 |
1 |
6.7% |
3 |
20.0% |
Group |
Mean ± SD (Days) |
Early Cranioplasty |
8.67 ± 2.94 |
Late Cranioplasty |
12.07 ± 3.10 |
Table 9: Blood Loss
Group |
Mean ± SD (mL) |
Median (mL) |
Early Cranioplasty |
209.33 ± 33.48 |
210 |
Late Cranioplasty |
346.67 ± 44.51 |
350 |
Table 10: Post-operative Complications
Complication |
Early (n=15) |
Follow-up |
Late (n=15) |
Follow-up |
Bone Flap Infection |
0 |
2 |
0 |
0 |
Hydrocephalus |
0 |
3 |
0 |
0 |
Seizure |
0 |
0 |
0 |
4 |
Table 11: Functional Outcome Scores
Barthel Index (BI)
Group |
On Admission (Mean ± SD) |
Follow-up (Mean ± SD) |
Early Cranioplasty |
71.00 ± 33.45 |
87.67 ± 20.17 |
Late Cranioplasty |
59.33 ± 34.43 |
74.00 ± 23.77 |
MMSE Score
Group |
On Admission (Mean ± SD) |
Follow-up (Mean ± SD) |
Early Cranioplasty |
17.13 ± 7.52 |
21.93 ± 6.73 |
Late Cranioplasty |
16.80 ± 10.65 |
18.07 ± 9.76 |
GCS Score
Group |
On Admission (Mean ± SD) |
Follow-up (Mean ± SD) |
Early Cranioplasty |
14.40 ± 1.80 |
14.93 ± 0.25 |
Late Cranioplasty |
13.66 ± 2.49 |
14.00 ± 2.10 |
GOS Score
Group |
On Admission (Mean ± SD) |
Follow-up (Mean ± SD) |
Early Cranioplasty |
4.47 ± 0.63 |
4.73 ± 0.46 |
Late Cranioplasty |
4.27 ± 0.80 |
4.40 ± 0.63 |
Table 12: Statistical Significance (Unpaired t-test)
Parameter |
Mean Difference |
T-value |
P-value |
Total Blood Loss |
-137.3 |
8.91 |
<0.05* |
Operative Time |
-0.83 |
5.80 |
<0.05* |
Hospital Stay |
-3.40 |
3.64 |
<0.05* |
Barthel Index (Follow-up) |
+13.67 |
1.70 |
0.10 |
MMSE (Follow-up) |
+3.87 |
1.26 |
0.22 |
GCS (Follow-up) |
+0.93 |
1.70 |
0.11 |
GOS (Follow-up) |
+0.33 |
1.65 |
0.11 |
*Statistically significant (p < 0.05)
Cranioplasty following decompressive craniectomy (DC) is more than a cosmetic procedure; it plays a pivotal role in restoring cerebral physiology, improving neurological function, and preventing complications such as sinking skin flap syndrome and hydrocephalus [1,2]. The timing of cranioplasty—whether performed early (within 3 months) or late (after 3 months)—has been an area of active investigation due to its potential impact on surgical morbidity, recovery time, and long-term outcomes.
In the present study, early cranioplasty (n = 15) was associated with significantly lower operative time (1.23 ± 0.26 hrs vs. 2.07 ± 0.65 hrs; p < 0.05), blood loss (209.33 ± 33.48 mL vs. 346.67 ± 44.51 mL; p < 0.05), and hospital stay (8.67 ± 2.94 days vs. 12.07 ± 3.10 days; p < 0.05) compared to the late cranioplasty group. These findings are consistent with prior reports, which suggest that delayed cranioplasty is associated with more extensive scarring, dural adherence, and brain tissue retraction—making surgical dissection more challenging and increasing the risk of dural tears and bleeding [3,4].
In our study, the incidence of dural tears was markedly higher in the late group (33.3% vs. 6.7%), reaffirming that surgical complexity increases over time due to fibrotic changes and scar maturation [5]. This mirrors results from Malcolm et al. [6], who observed increased operative complications with delayed intervention.
Regarding neurological outcomes, both groups demonstrated improvement across all functional scales (GCS, GOS, MMSE, and Barthel Index). However, the early cranioplasty group showed greater improvements at the 3-month follow-up, although statistical significance was not reached for most neurological parameters. This trend supports studies by Shahid et al. [7] and Di Stefano et al. [8], who reported earlier and more substantial cognitive recovery in patients undergoing early reconstruction due to restoration of cerebral blood flow and normalization of intracranial pressure dynamics.
Our findings also align with Stone et al. [9] and Xu et al. [10], who performed meta-analyses confirming that early cranioplasty leads to better functional outcomes and fewer complications in select patient populations. However, early cranioplasty must be cautiously considered in patients with unresolved cerebral edema, infection, or systemic instability—conditions where delayed intervention may be justified [11].
An important observation in our study was the difference in complication patterns. While infections were minimal in both groups, seizures were more frequent in the late group during follow-up (4 patients), although not statistically analyzed due to small sample size. Previous literature suggests that delayed cranioplasty may increase seizure risk due to prolonged cortical irritation and impaired autoregulation [12].
The choice of cranioplasty material also varied, with autologous bone being more common in the early group and bone cement more frequently used in the late group. This is expected, as prolonged storage of bone flaps (especially in the abdomen) can increase the risk of resorption or contamination, necessitating synthetic substitutes [13].
Despite the small sample size, our study reinforces the growing consensus that early cranioplasty (within 3 months) is generally safer, faster, and associated with improved early neurological recovery. The results emphasize the importance of individualized patient selection, adequate infection control, and standardized perioperative protocols to minimize risks regardless of timing.
This study demonstrates that early cranioplasty (within 3 months of decompressive craniectomy) is associated with significantly lower intraoperative blood loss, shorter operative time, and reduced hospital stay compared to late cranioplasty. Although the differences in neurological outcome scores (GCS, GOS, MMSE, and Barthel Index) between the two groups were not statistically significant, early cranioplasty showed a trend toward better functional recovery. Additionally, the early group experienced fewer surgical complications, particularly dural tears.
These findings suggest that, in the absence of contraindications such as infection or unresolved cerebral edema, early cranioplasty is a safe and effective strategy that may facilitate better surgical and neurological outcomes. Timing should be individualized based on patient condition, but early reconstruction can be considered favorable in most clinical scenarios
1. Honeybul S, Ho KM. Cranioplasty: Morbidity and failure. Br J Neurosurg. 2016;30(5):523–528.
2. Gooch MR, Gin GE, Kenning TJ, German JW. Complications of cranioplasty following decompressive craniectomy: Analysis of 62 cases. Neurosurg Focus. 2009;26(6):E9.
3. Tasiou A, Giannis T, Georgiadis I, et al. Cranioplasty outcomes and complications: A single-center analysis of 220 cases. Acta Neurochir (Wien). 2015;157(9):1601–1608.
4. Nalbach SV, Ropper AE, Dunn IF, et al. Infections following cranioplasty: Incidence, timing, and predictors in 348 cases. J Clin Neurosci. 2011;18(3):397–401.
5. Piedra MP, Ragel BT, Zhang Y, et al. Timing of cranioplasty after decompressive craniectomy for trauma. Surg Neurol Int. 2014;5:25.
6. Malcolm JG, Mahmooth Z, Rindler RS, et al. Early cranioplasty is associated with greater neurological improvement: A systematic review and meta-analysis. Neurosurgery. 2018;82(3):278–288.
7. Shahid AH, Mohanty M, Singla N, et al. Early cranioplasty may improve cerebral perfusion and cognitive function in patients with large decompressive craniectomy. World Neurosurg. 2018;117:e245–e251.
8. Di Stefano C, Rinaldesi ML, Quinquinio C, et al. Improvement of cerebral hemodynamics and neuropsychological recovery after cranioplasty: A prospective study. Clin Neurol Neurosurg. 2013;115(11):1926–1930.
9. Stone J, Lownie SP, Pelz DM, et al. Cranioplasty: A review of the indications and timing in patients undergoing decompressive craniectomy. World Neurosurg. 2016;87:579–585.
10. Xu H, Tang W, Han N, et al. Timing of cranioplasty after decompressive craniectomy: A systematic review and meta-analysis. World Neurosurg. 2019;127:630–640.
11. Yadla S, Campbell PG, Chitale R, et al. Effect of early surgery, material, and method of flap preservation on cranioplasty infections: A meta-analysis. Neurosurgery. 2011;68(5):1124–1130.
12. Thavara N, Saeheng S, Suwanwela NC. Post-cranioplasty seizures: Risk factors and incidence. Neurol Res Int. 2020;2020:8356780.
13. Kim HJ, Kim CH, Kim Y, et al. Long-term outcomes of autologous bone flap after decompressive craniectomy. J Korean Neurosurg Soc. 2016;59(3):255–260.
14. Panchal D, Patra DP, Mukherjee D, et al. Neurological improvement after cranioplasty: Review of the literature. Surg Neurol Int. 2015;6:19.