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Research Article | Volume 13 Issue:3 (, 2023) | Pages 1338 - 1342
Improvement in Lipid Profile after Starting Metformin in Prediabetic Patient- An Observational Study
Under a Creative Commons license
Open Access
Received
July 3, 2023
Revised
July 11, 2023
Accepted
July 21, 2023
Published
Aug. 23, 2023
Abstract

Background- Additionally, the prevalence of prediabetes in India ranged from 10% to 14%, which is higher than the global prevalence of 8%. Dyslipidemia, characterized by elevated levels of low-density lipoprotein cholesterol (LDLc), elevated tri-acylglycerol (TG), and decreased levels of high-density lipoprotein cholesterol (HDLc), is linked to an augmented risk of cardiovascular disease (CVD). Consequently, the timely identification and management of dyslipidemia can significantly contribute to the prevention of cardiovascular morbidity and mortality. Methods- This is a Prospective observational cohort study, A total of 240 patients from Outpatient department (OPD) and Indoor patient (IPD) department of Medicine, Dr. Baba Saheb Ambedkar Medical college and Hospital, New Delhi, were taken for study considering the inclusion and exclusion criteria. The data was collected in a pre test proforma which includes various socio-economic parameters like age, sex, occupation, religion, etc Results - The mean age of participants was 53.020+-16.5 years, and mean BMI of 24.555±12.8 kg/m2. All patients, exhibited total cholesterol levels that fell within the range considered to be normal following the administration of the prescribed therapy. The mean total cholesterol level recorded was 141.2mg/dl. In the study, it was observed that 75% of the participants experienced a reduction in their cholesterol levels. On the other hand, a small percentage of 1.25% showed an increase in their cholesterol levels. Additionally, 23% of the participants demonstrated no significant change in their cholesterol levels, with a margin of error of plus or minus 10mg/dl, when compared to their baseline measurements. Conclusion- There was a notable enhancement in the average values (moving closer to the normal distribution) of each lipid profile parameter over time. The findings of the study indicate that the utilization of metformin resulted in improvements in lipid parameters.

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