European Journal of Cardiovascular Medicine

Serum uric acid (SUA) level is one of the cardiovascular risk factors, according to numerous researches. The purpose of the research is to determine how SUA levels relate to the severity of coronary artery disease (CAD) in patients with acute coronary syndrome(ACS) as determined by angiography and the Syntax score. Method : This investigation was done in patients who came to our institution with acute coronary syndrome between August 2022 and September 2023. Following admission, SUA and other blood parameters were ascertained. Initially, the patients were categorized into three groups based on their Syntax scores: low, moderate, and high. The low group included scores ≤22, intermediate (22-33), and high scores (>33). Results: The study included 150 patients. The mean age of the study population was 60.5 ± 8.0 years. 52 were female (34.6%) and 98 were male (65.3%). Of the patients, 60.0% had hypertension, 55.6% had diabetes mellitus, 60.0% had smoking, 75.3% had dyslipidemia. The mean SYNTAX score was 16.6 ± 11.9. According to the SYNTAX score (31.1 %) had mild CAD (SYNTAX score: 1–22), (38.9%) had moderate CAD (SYNTAX score: 23–32), and had 33% severe CAD (SYNTAX score: ≥ 33). The mean SUA values were 5.23 ± 1.4 mg/dL in the mild CAD group, 6.0 ± 1.4 mg/dL in the moderate CAD group, and 6.7 ± 1.6 mg/dL in the severe CAD group. According to Spearman’s rho analysis, a positive correlation between the SUA levels and the SYNTAX score was determined to be statistically significant (p < 0.001, r = 0.240; p = 0.002, r = 0.150 in men; p = 0.001, r = 0.203 in women). Conclusions: SUA levels are associated with the severity of CAD in patients with ACS. An elevated SUA may be useful as a biomarker of the severity of CAD.