Impact of PlA2 Polymorphism on Cardiovascular
Disease and Outcome after Percutaneous Coronary Intervention: A Review of Current Evidence and Future Perspectives

doi:10.5083/ejcm.20424884.04.02

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Review Article | Volume:1 Issue 4: (, 2011) | Pages 11 - 20

Impact of PlA2 Polymorphism on Cardiovascular Disease and Outcome after Percutaneous Coronary Intervention: A Review of Current Evidence and Future Perspectives

Roberta De Rosa, MD, Gennaro Galasso, MD, PhD, Guido Iaccarino, MD, PhD, Salvatore Cassese, MD, Raffaele Piccolo, MD, Teresa Strisciuglio, MD & Federico Piscione, MD, PhD

Under a Creative Commons license

Open Access

DOI : 10.5083/ejcm.20424884.04.02

Published

Dec. 25, 2010

Abstract

Coronary artery disease (CAD) is a multifactorial disease with the environment and multiple genes implicated in its pathogenesis. Thus, during the last decade several genes involved in the athero- sclerotic process and their polymorphisms have been suspected to increase the thrombotic predisposition and to influence the risk for acute coronary syndromes (ACS). It is well-known that platelets play a significant role in the pathogenesis and development of CAD and its clinical manifestations. Therefore, platelet polymorphisms have been extensively studied in order to clarify their contribution to atherothrombotic process and their role in CAD.

Keywords

Coronary artery disease

European Journal of Cardiovascular Medicine

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