Background: In recent years, there has been a greater emphasis on the epidemiological of mistakes and adverse outcomes rather than on procedures that decrease such incidents. aim of study is to: Assess nurses Knowledge regarding preoperative nursing safety practices for cardiac catheterization patients. Methodology: The descriptive research design was utilized for this study. and the sitting of the study was at AL Hussein teaching hospital in Al muthanna governorate. The subjects of the study consisted of all nurses (30 nurses) working at the above mentioned. The toll of the study included the safety practices in the postoperative phase cardiac catheterization. These were categorized a checklist related to the availability of the equipment and safety items provided for patients at the catheterization unit. This checklist items was checked as being either available (2) ,or (1) not available (0). As regard safety it is a three Likert scale ranged from done completely (2), done incompletely (1), to not done (0). Result: the main results of study reveal that, there was no a highly significant relation between socio-demographic characteristics and nursing safety practices for cardiac catheterization patients at preoperative phase. Conclusion: the studied nurses had no significance in practicing safety practices in cardiac catheterization centers. Educational levels and years of experience had no statistical significant effects on nurses' safety practices. Recommendation: Pre- services on the job training programs are advocated for all nurses about patients' safety in nursing work requirement and utilize the results of the current study to ameliorate& update cardiac catheterization patient’s safety practices with continuing evaluation.