European Journal of Cardiovascular Medicine

Objective: The objective of this study was to evaluate the correlation between time domain analysis of heart rate variability and glycated haemoglobin levels, as well as the duration of type II diabetes mellitus. Methodology: A cohort of 38 male participants, with ages ranging from 40 to 65 years, underwent evaluation. The participants were divided into two distinct groups; diabetic and control group. The study covered several procedures, including blood collection, measurement of body composition, autonomic testing, and cardiopulmonary exercise testing. The process of capturing and documenting the instantaneous R-R intervals (RRi) was conducted with the purpose of enabling the later examination of heart rate variability (HRV). The participants were provided with explicit instructions to refrain from participating in moderate or vigorous physical activity, consuming meals, stimulating substances, or alcoholic beverages for a duration of 24 hours preceding the evaluations. Furthermore, participants were mandated to observe a fasting period lasting 12 hours on the day of blood sample collection. Results: The mean age of the diabetic group was 51.53 ± 5.86 years, with a body mass index of 28.62 ± 3.19 kgm2. The average systolic blood pressure in the diabetic group was 138.4 ± 99.45 (mg/dL), diastolic blood pressure was 81.45 ± 14.56 (mg/dL), mean heart rate was observed as 85.6 ± 7.32 (beat/mint) SDNN was 22.1 ± 6.5 (ms).A positive correlation was observed between heart rate, Hb1Ac and diabetes duration. Meanwhile, a negative correlation was observed among other parameters. Conclusion: In conclusion, we have made a significant finding that heart rate variability can be utilized as a beneficial diagnostic tool for identifying cardiac autonomic neuropathy, a medical ailment that arises due to persistent hyperglycemia.