European Journal of Cardiovascular Medicine

Background: Breast carcinoma is one of the leading causes of malignancy in females, constituting about 20% of all malignancies. Major cause of death in breast cancer is due to dissemination of primary tumour leading to metastasis. Spread to axillary lymph nodes is often the first step of metastasis. In general, tumour size, nuclear grade, mitotic activity, lymphatic and vascular invasion and lymph node involvement along with clinical features including the presenting complaints, menstrual history and family history collectively aid in assessment of severity of breast cancer. Methodology: Sixty cases of breast carcinoma were evaluated in department of pathology of SNMC and HSK Hospital between 01-01-2014 and 31-12-2015 of which 01-01-2014 to 30-11-2014 involved collection of retrospective data and from 01-12-2014 to 31-12-2015 prospective data. The specimens received were fixed and processed routinely; 3-4 micrometer thin sections were prepared and stained with H and E. Histopathological evaluation and grading were done based on Modified Scarff Bloom Richardson grading system. Results: Out of 60 cases, 54 were IDC-NOS type. Invasive Lobular Carcinoma (ILC), Papillary carcinoma and Mucinous carcinoma were noted in two cases each. Lymph nodes metastasis was seen in 55% of cases. Conclusion: In present study, an attempt has been made to highlight the importance of histopathological examination in breast carcinoma and predict prognosis based on histological grades.