European Journal of Cardiovascular Medicine

Introduction: The aim of our study was to compare the effectiveness of both TA and EACA in reducing post surgical bleeding in on-pump CABG surgeries with regards to the amount of blood loss at 4 hrs and 24 hrs asthe primary outcome. Materials and Methods: After the completion of surgery patients were shifted to ICUand were assessed for blood loss at 4 hrs and 24 hrs after shifting. Indication for transfusion of PRBC was a haemoglobin level of <8gm/dl. FFP was trasfused if post operative drain was > 250ml/hr in first hour. Platelet trasfusion was indicated if platelets counts were <50000/mm3. Results: The requirement of PRBC in group TA was for 4patients, where as in EACA group 5patients required PRBC (P>0.05). One patient in each group required FFP transfusion (P>0.05).Both the groups did not require any platelet transfusion & the transfusion rate was non-significant between the groups. Both the groups had no re exploration due to excessivebleeding. Conclusion: Based on the results of our study it can be concluded that both TA & EACA effectively inhibits fibrinolysis during on pump CABG surgery and thus results in decreased post operative bleeding. When compared between the two, TA was slightly better with respect to post operative bleeding at 24hrs