European Journal of Cardiovascular Medicine

Myocardial bridging, characterized by a segment of the coronary artery tunneled through myocardial tissue, varies significantly in its clinical manifestation and relevance. Despite its frequent observation during coronary angiography, its implications remain controversial. This study aims to clarify the anatomical and clinical significance of myocardial bridging through a comprehensive analysis of human cadavers. Objectives: The primary objectives are to evaluate the prevalence and morphological characteristics of myocardial bridging in a diverse set of human cadavers and to correlate these findings with potential clinical implications, including its role in myocardial ischemia and sudden cardiac death. Methods: A total of 150 cadavers were systematically dissected to examine the presence, location, length, and depth of myocardial bridges over the coronary arteries. Each identified bridge was assessed for arterial involvement and measured for dimensions. The data were then analyzed statistically to determine the prevalence and morphological patterns, followed by a review of clinical records when available to hypothesize the clinical relevance of the findings. Results: Myocardial bridges were observed in 45% of the cadavers, with the most common location being the mid-segment of the left anterior descending artery. The average length and depth of the bridges were significantly associated with the occurrence of severe coronary artery disease in the corresponding vessel. A noteworthy correlation was found between deeper and longer bridges and records of myocardial ischemia or sudden death, suggesting a potential clinical impact. Conclusion: The study confirms the substantial prevalence of myocardial bridging in a general population and provides detailed anatomical descriptions. The correlation between bridge characteristics and adverse cardiac events underscores the clinical significance of thorough cardiovascular assessment and management in patients with diagnosed myocardial bridging. Further research is necessary to understand the pathophysiological mechanisms and to develop effective strategies for risk stratification and treatment.