Background: A home-based intervention is a promising approach for early intervention about HAV that aims at improving mothers-child outcomes. The aim of this study was to examine the effect of home based intervention on improving mothers' perception about Hepatitis A virus. Methods: Design: A quasi- experimental (pre-post) design was utilized. Subjects: A multi stage random sample of 360 mothers through home visits in Shranees village, Quesna district at Menoufia Governorate, Egypt. Instruments: 1) Hepatitis A virus Interview Questionnaire to assess socio-demographic data and mother's perception of hepatitis A virus which included mothers' knowledge about hepatitis A virus and mothers' practices about HAV and 2) Observational checklist to assess home environment and to assess home feeding environment