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Research Article | Volume 12 Issue :3 (, 2022) | Pages 66 - 71
Antenatal screening for Hemoglobinopathies with HPLC and their Fetomaternal Outcome
Under a Creative Commons license
Open Access
DOI : 10.5083/ejcm
Published
Sept. 30, 2022
Abstract

Introduction: Hemoglobinopathies are diverse group of inherited disorders of hemoglobin production and function. They represent the most common single-gene disorders that are found in humans and are distributed in various frequencies throughout the world. Pregnancy in women with sickle cell disease can increase the risk of maternal and perinatal mortality. HPLC offers the advantages over the routine Hemoglobin electrophoresis as it can more accurately identify and quantitate abnormal hemoglobin. HPLC forms an accurate, rapid and reproducible tool for early detection and management of thalassemia and abnormal hemoglobin variants

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