Background: Burst Abdomen is a preventable condition in which many risk factors play their role and lead to life threatening complications. This study's goal was to evaluate the incidence and risk factors, of burst abdomen in patients receiving midline laparotomies. Patients and methods: 240 patients who underwent midline laparotomies at Government Medical College in CENTRAL INDIA between January 2021 and December 2021 were the subjects of a prospective cohort research. Online available Software was used to monitor and analyse factors including age, sex, BMI, substance abuse, previous laparotomy, malignancy, diabetes mellitus, ascites, albumin, renal functions, bilirubin, haemoglobin, intra-abdominal pathology, suture material, creation of stoma, postoperative chest infection, postoperative paralytic ileus, leakage, and wound infection. Results: Incidence of burst abdomen was 11.25% among patients who underwent laparotomy. The following statistically significant factors (P<0.001) were linked to burst abdomen: wound infections, anaemia, uncontrolled diabetes, hypoalbuminemia, previous laparotomy, development of stoma, chest issues, ascites, postoperative cough, postoperative leakage, and peritonitis. In this investigation, we did not find any statistically significant relationships between patient sex, age, concomitant morbidities including jaundice and uremia, past steroid use, suture material utilised in closure, and postoperative paralytic ileus. Conclusion: According to the results of our study, significant risk factors for burst abdomen included wound infection, anaemia, previous laparotomy, stoma creation, hypoalbuminemia, ascites, diabetes, type of intra-abdominal pathology, with maximum incidences in peritonitis, postoperative cough, and postoperative leakage