Objective: To evaluate the interaction between Thyroid hormones and Glucose homeostasis in post menopausal Diabetic and Non-Diabetic women. Materials and Methods: The study was conducted in the Department of General Medicine, Sapthagiri Institute of Medical Sciences & Research Center, Bangalore. 40 Post menopausal Non-diabetic women attending OPD, Department of Medicine. Anthropometric & Physiological parameters were taken. Complete blood picture count, Fasting blood glucose(FBS),Glycosylated haemoglobin(HbA1C), Oestradiol, progesterone, Follicle stimulating hormone(FSH), Luteinizing hormone(LH) levels were analyzed