European Journal of Cardiovascular Medicine

Background:- Diabetes is a long-standing condition affecting kidneys and resulting into chronic kidney disease (CKD) as one of its major complications. In diabetic CKD there is generation of free radicals which further deteriorates kidney function. These free radicals lead to the formation of Malondialdehyde (MDA) which indicates the extent of oxidative stress (OS). Present study aims to evaluate the level of oxidative stress among diabetic CKD patients and to know its correlation with other parameters. Material and Method:- This study was comprised of 108 diabetic CKD patients from different hospitals of Lucknow in the period between November 2020 to June 2021. A control group consisting of 132 people was also taken for comparison. Study design was cross-sectional and observational. Biochemical profile including serum MDA of patient and control group was analysed using an auto analyzer. Chi-square, Pearson's correlation and t-test were applied to see association, correlation & comparison respectively between different variables. P-value was considered statistically significant if it is <0.01 for Pearson's correlation and <0.05 for other tests. Results:- Statistically significant rise in blood urea, serum creatinine , uric acid and MDA in diabetic CKD patients was observed than control group. A significant level of dyslipidemia also existed in the patients. MDA was shown to be positively and significantly correlated with serum creatinine, blood urea and serum uric acid while a negative significant correlation was there between MDA and eGFR. Conclusion:- In diabetic CKD, dyslipidemia and increased level of oxidative stress is very common. Anti‑oxidant treatment and hypolipidemic therapy may be of value. Decreasing the uric acid levels may also be a new approach in the management of diabetic CKD as MDA was seen to be significantly correlated with serum uric acid.