Introduction: Some studies have reported an association between ischaemia of the macula as seen on fundus fluorescein angiography (FFA) with diabetic nephropathy in diabetes mellitus. They have further postulated that finding of macular ischaemia on FFA can be used to predict the onset of diabetic nephropathy in diabetes mellitus. This study was undertaken to explore association between macular ischemia and nephropathy in diabetes mellitus in a rural population of Maharashtra. Aims and objectives: To explore for any correlation between ischaemic maculopathy due to diabetes and diabetic nephropathy and to find out whether ischaemic maculopathy can be used as a marker for diabetic retinopathy.