European Journal of Cardiovascular Medicine

The purpose of the current study is to evaluate the impact of low dose isotretinoin therapy on the changes of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol in acne vulgaris patients. Methodology: Fifty patients with moderate to severe acne who were attending the dermatology department and were between the ages of 15 and 45 were treated with 20 mg of isotretinoin every day for four months. Blood samples were taken on day 0, the second week, the first, second, third, and fourth months. Results: The measured baseline cholesterol levels in the continuous therapy group were 116.86 ± 23.55, and they grew above the baseline levels at each subsequent interval of 4 weeks, 8 weeks, 12 weeks, 16 weeks, and at the end of the treatment. The P-value is significant when compared to the baseline. At all time points, compared to baseline and above the normal limit, there was a statistically significant increase in cholesterol, triglycerides, and LDL. There was also a statistically significant decline in HDL levels. Conclusion: Increase in cholesterol, triglycerides, and LDL over the usual range was brought on by low dosage continuous isotretinoin therapy. HDL values fluctuate with grade 1 (increase and decrease). Mild, well-tolerated side effects did not need therapy discontinuation. So it's crucial to raise awareness of the implications. We tell our expert that using low dose isotretinoin for moderate to severe acne can be done with little worry, although close monitoring is crucial