Introduction: One of the most frequent causes of acute abdomen in nearly all age groups is acute appendicitis and emergency appendectomy is one of the most common surgeries being performed worldwide.This classic presentation occurs in only 50%– 60% of patients and the diagnosis may be missed or delayed when atypical patterns of disease are encountered.Material and Methods. This study was conducted study at Government Medical College Srinagar J&K India over a period of 2 years.117 patients above the age of 14 years who underwent emergency appendectomy for suspected acute appendicitis were enrolled as study subjects. This study aims to study the diagnostic accuracy of ultrasonography, total leucocyte count and neutrophil percentage in diagnosing acute appendicitis. Results Ultrasonography, Neutrophil Percentage andLeucocyte count had a sensitivity of 81%, 74% and 70% respectively for acute appendicitis. Sensitivity decreased (53%) when raised TLC, NP and USG were used together to predict appendicitis but specificity increased markedly (94.1%) pointing to the fact appendicitis was highly unlikely if all these tests were simultaneously negative.Conclusion.The results showed that normal blood parameters (total leucocyte count and neutrophil percentage) along with normal ultrasonography have a high combined diagnostic accuracy for acute appendicitis