Background: Despite advances in diagnosis, management and critical care of patients with peritonitis due to hollow viscus perforation, prognosis remains poor. Early assessment by scoring systems will influence the management and prognosis. Aim: Evaluation of Mannheim Peritonitis Index (MPI) score for predicting the outcome in patients with peritonitis. Materials and Methods: Prospective study of 60 patients admitted and operated for peritonitis in. The structured scoring system i.e. MPI was applied along with other clinical and biochemical parameters recorded in pre-structured proforma. Data was analysed for predicting mortality and morbidity using EPI info and SPSS software. Results: The overall mortality was20%. MPI scores of <21, 21-29, and ≥ 30 had a mortality of 6.67%, 13.4%, and 0% respectively. In our study ACCURACY of Mannheim peritonitis index (MPI) to grade the severity of acute peritonitis is 72.9%, SENSITIVITY is16.7%, SPECIFICITY is 79.2% Conclusion: MPI is disease specific, easy scoring system for predicting the mortality in patients with secondary peritonitis. Increasing scores are associated with poorer prognosis, needs intensive management and hence it should be used routinely in clinical practice