Introduction: Peptic ulcer disease is a disease of gastric and duodenal ulcers. This ulcer is a major threat worldwide over the past two centuries with a high morbidity and mortality. There are also some studies suggested that there is a complications that is seen after post operative peptic ulcer. Objective: To study postoperative complication in peptic ulcer disease patients in tertiary care hospital. Material: A prospective study conducted on 180 post operative peptic ulcer patients. This study was conducted in department of surgery and patient ready to give inform consent form. This study was carried out after taking approval from institute ethical committee permission. Results: The present study was carried out on 186 pre operative peptic ulcer patients among them majority of the patients were males with a age group under 41 to 50 years. Out of 186 patients, 45.16% patients having ulcers among them multiples ulcer was observed in 61.90% .symptoms such as epigastric pain (90.32%) and gastritis (74.19%) was observed in most of the patients. 83.33% not taken any drugs 16.66% has taken drugs like NSAIDs taken by 74.19%. surgery 34.40% having no complication and 65.59% having complications, majority of the patients having surgical site infection (26.22%) followed by pleural effusion and diarrhea respectively. Conclusion: Mostly this peptic ulcer is seen in employs and students, patients taking NSAIDs, mostly seen in diabetes patients, symptoms like epigastric pain and post-operative complication like infection at the surgical site is mostly seen