Contents
Download PDF
pdf Download XML
261 Views
97 Downloads
Share this article
Research Article | Volume 13 Issue:1 (, 2023) | Pages 1193 - 1200
Efficacy of Frozen Section in Rapid Diagnosis of Central Nervous System Neoplasms: An Experience in A Tertiary Health Care Center in Eastern Odisha
Under a Creative Commons license
Open Access
DOI : 10.5083/ejcm
Published
March 24, 2023
Abstract

Objective: The primary goal of the intraoperative Frozen Section biopsy in a clinically suspected Central Nervous System (CNS) neoplasm is to evaluate the submitted tissue for rapid diagnosis, which helps in proper management during open craniotomy. In this study, the accuracy of frozen section in the diagnosis of CNS neoplasms and discrepancies in diagnosis were analyzed. Material & Methods: Ninety cases of CNS neoplasms were examined over a period of one year. All the cases were open biopsies performed at Neurosurgery Department &intra-operative frozen section (by cryostat) was performed & reported in the Histopathology section of a referral center in Eastern Odisha. The diagnoses given on FS were compared with the final diagnosis given on permanent paraffin embedded tissue sections. Results: In all cases, cryostat sections were prepared and a provisional diagnosis was given. Final histopathological diagnosis was given by studying the Hematoxylin & Eosin (H&E) section. Out of these 90 cases, 81 cases (90.0 %) were concordant, 9 cases (10.0 %) were discrepant. The discrepancies occur in mainly differentiating astrocytomas from oligodendrogliomas & schwannoma from meningioma along with few over-grading of glioma cases. Conclusion: Our results showed a reasonably high percentage of accuracy in the intraoperative diagnosis of CNS lesions. However, freezing artifact, obscuring cytological detail, heterogenous features of gliomas and lack of proper clinical inputs were the major causes for discrepancies

Keywords
Recommended Articles
Research Article
Role of Conventional MRI with MR Spectroscopy in Evaluation of Intracranial Space Occupying Lesions
...
Published: 30/08/2025
Download PDF
Research Article
A Study on Clinical Profile of Children with Congenital Heart Disease Attending Tertiary Care Hospital
...
Published: 30/08/2025
Download PDF
Research Article
Role of Ultrasound Guided Inferior Venacaval Collapsibility Index in Predicting Hemodynamic Changes During Spinal Anaesthesia
...
Published: 02/09/2025
Download PDF
Research Article
Clinical Spectrum and Outcomes of Ophthalmia Neonatorum: A Prospective Observational Study
Published: 01/09/2025
Download PDF
Chat on WhatsApp
Copyright © EJCM Publisher. All Rights Reserved.