European Journal of Cardiovascular Medicine

Introduction: Tuberculosis (TB) is a communicable disease that is a major cause of ill health and one of the leading causes of death worldwide. Monocytes are professional phagocytes that are highly skilled in defence against many pathogens, including MTB.4 They circulate in the blood and can differentiate into monocyte-derived macrophages and monocyte-derived dendritic cells that govern innate and adaptive immune responses and Lymphocytes (L) provide resistance to the spread of infection causing mycobacterial clearance. Aim & Objectives: To assess the monocyte lymphocyte ratio (M/L ratio) as a possible prognostic biomarker to see the outcome of Anti Tuberculous Therapy in terms of sputum status in active TB cases. Material & Methods: The present study was a Prospective observational study. This study was conducted from Feb 2021 and July 2022 at Department of respiratory medicine, Kamla Nehru Chest Hospital, Dr S N Medical College Jodhpur, a tertiary care Centre for respiratory diseases, Rajasthan, India. 130 patients were included in this study. Result: In our study, 7 (5.4%) patients had COPD, 23 (17.7%) patients had HTN and 18 (13.8%) patients had T2DM. The value of z is 9.8029. The value of p is < .00001. The result is significant at p <.05. In our study, 130 (100.0%) patients had Sputum Status at 0 month. In our study, 117 (90.0%) patients had Sputum conversion at 2nd month. The value of z is 12.8996. The value of p is < .00001. The result is significant at p <.05. The mean Monocytes at 0 Month of patients was [5.0769± 1.2519], mean Lymphocytes at 0 Month of patients was [17.7392± 4.3696], mean M/L ratio at 0 Month of patients was [.3057± .1206], mean Monocytes at 2nd Month of patients was [4.4862± 1.1302] and mean M/L ratio at 2nd Month of patients was [.2389± .0821]. Conclusion: Tuberculosis ss associated with Increased M/L Ratio, which Declines and Returns to Normal with Anti-Tuberculous Therapy.