Introduction: Diabetic retinopathy is a vascular condition of the retina that develops as a result of diabetes mellitus (DM). This study aimed to compare intravitreal bevacizumab, pan-retinal photocoagulation or a combination of both in proliferative diabetic retinopathy. Method: In this prospective, randomized interventional study, 180 patients with PDR were enrolled and divided into three equal groups, i.e., Group A-patients treated with laser alone and Group B- patients treated with Anti-VEGF alone and Group C- patients treated with Anti-VEGF and laser. A detailed history, clinical and demographical data of all the patients were recorded and compared.The examination was done, including visual acuity assessment with Snellen’s chart, Slit-lamp biomicroscopic examination, intraocular pressure and pupillary assessment for optic nerve dysfunction.