Aim and objective: To Examine the effect of addition of dexamethasone and clonidine to local anaesthetic drug in (0.5% Bupivacaine+ 2% lignocaine with adrenaline) in PNS guided Supraclavicular brachial plexus block. Methodology: 90 patients presenting for upper limb surgery were divided into three groups. Group D receive Dexamethasone 8 mg as an adjuvant to Bupivacaine+ lignocaine whereas Group C receive Clonidine 75 mcg as an adjuvant to bupivacaine+ lignocaine and Group S is control group receiving saline as an adjuvant to bupivacaine+ lignocaine with adrenaline in Supraclavicular Brachial Plexus block