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Research Article | Volume 13 Issue:1 (, 2023) | Pages 400 - 407
Drug–Drug Interactions among Critically Ill Patients with Chronic Kidney Disease Management
Under a Creative Commons license
Open Access
DOI : 10.5083/ejcm
Published
Feb. 9, 2023
Abstract

Background: Chronic kidney disease (CKD) is a long-term condition characterized by a gradual loss of kidney functions, usually accompanied by other comorbidities including cardiovascular diseases (hypertension, heart failure and stroke) and diabetes mellitus. Epidemiological and clinical observations have shown that polypharmacy may increase the probability of adverse drug reactions (ADRs), possibly through a higher risk of drug-drug interactions (DDIs). Renal impairment may further worsen this scenario by affecting the physiological and biochemical pathways underlying pharmacokinetics and ultimately modifying the pharmacodynamic responses

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