European Journal of Cardiovascular Medicine

Introduction: Type-2 diabetes mellitus are reported to have a 2 to 3-fold increase in the incidence of cholesterol gallstones. Gallstone disease in patients with diabetes mellitus is largely due to dyslipidemia, leading to the alteration in the composition of bile. Impairment of gallbladder motility and contraction, as a result of hyperglycemia and diabetic autonomic neuropathy. Hence the study is undertaken to determine prevalence of gall-bladder disorders in diabetic patients with autonomic neuropathy and association of different parmaetrs with Cases and without autonomic neuropathy. Material & Methods: This was a hospital based case-control study carried out during the period of October 2010 to October 2012. Institutional ethics committee approved the study.The study comprised of known or newly diagnosed 101 patients of type-2 diabetes mellitus and 101 age and sex matched controls. Observation & Results: Out of 101 cases studied 67(66.33%) had autonomic neuropathy and out of 101 controls 9(8.91%) had autonomic neuropathy. Thus prevalence of autonomic neuropathy was significantly more in cases than controls.  Out of 67 cases with autonomic neuropathy 32 (47.76%) had gallbladder disorders and out of 34 cases without autonomic neuropathy 4(11.76%) had gallbladder disorders. Thus prevalence of gallbladder disorders in cases with autonomic neuropathy was significantly more than in cases without autonomic neuropathy. Conclusion: Present study concluded that Gallbladder disorders are significantly associated with metabolic syndrome in type-2 diabetics.Type-2 diabetics with autonomic neuropathy have larger gall bladders with poor contraction in response to fatty meals, thus predisposing these patients to various forms of gall bladder disease