Background: Elevated Lp (a) and heart disease & indicates that Lp (a) is an important, independent predictor of cardiovascular disease. Objective: To evaluate the level and effect of lipoprotein (a) in CKD patients. Methods: The present study was conducted at the PG Department of Medicine of S.N. Medical College, Agra. The tests used for the determination of left ventricular hypertrophy were done by echocardiography (quantitatively) and by ECG (qualitatively). Results: Maximum number of subjects were male (60%). Maximum number of patients were between the age of 41-50 yrs (43%). The level of lipoprotein (a) was significantly increased in hemodialysis group. Lp (a) level was measured at the baseline, 3 month and 6 month in both groups and when analyzed statistically the P value was (0.7668), (0.0413) and (0.0495) respectively.This data is suggestive that P value is significant at 3 month and 6 month which means increase in Lp (a) level at 3 month and 6 month was positively correlated with hemodialysis. LVH had a positive correlation with hemodialysis group Conclusions: Lipoprotein (a) level is more in hemodialysis patients.