Aim and objective -To compare with different site of infection & comorbidities among study group Study of various clinical features to rule out accurate diagnosis. To use negative pressure wound therapy (NPWT) in patients with chronic venous leg ulceration. Material and method- The present study was conducted in department of general surgery Rajshree medical research institute , BareillyThis is an observation and comparative type of study. Result and conclusion- Healing of chronic leg ulcer is a complex process attributed to several elements. Although various parameters earlier proved to positively affect the healing of ulcers but the present study recommends that V.A.C. therapy should be considered as the treatment of choice for chronic leg ulcers owing to its significant advantages in the time to complete healing compared with conventional wound care. In this present study V.A.C. therapy overall appears to be superior to other wound care techniques