European Journal of Cardiovascular Medicine

Background: The most significant cause of infant fatalities in the neighborhood is neonatal sepsis. Objective: To identify the typical bacterial infections linked to neonatal sepsis, as well as their pattern of antibiotic sensitivity. Materials and Methods: A total of 100 newborns admitted to the neonatology unit during the study period had their physical examinations and clinical characteristics. All infants were observed using conventional methods and the Kirby-Bauer disc diffusion method. Samples were also tested for standard antibiotic sensitivity.  Results: The present study showed that out of 100 clinically suspected neonatal sepsis cases. 44% newborn sepsis patients with clinical suspicion and positive screening test results were confirmed by culture. The majority pathogen in the culture-positive cases was discovered to be Gram Negative 66% (n= 29); among them 62.06% (n=18) belonged to EONS and 37.93% (n=11) belonged to LONS. Klebsiella pneumoniae 46.15 % (n=12) was the most common isolate followed by Escherichia coli  23.06 %(n=6) whereas 34 % (n=15) were Gram Positive isolates. Out of 15 Gram-Positive isolates, 53.33% (n=8) were of EONS and 46.7 % (n=7) were of LONS. Staphylococcus aureus 19.23% (n=5) was the most common isolate followed by CoNS 7.69 %(n=2) and Enterococcus faecalis 3.85% (n=1).  Conclusion: The timely diagnosis and prompt use of antibiotics according to standard policy is warranted to save newborns from septicemia. Knowing the bacterial infections that are widespread in NICUs and their antimicrobial susceptibility pattern can assist the doctor choose the right drugs for treating cases of suspected newborn sepsis in light of the developing bacterial resistance to commonly used antibiotics