European Journal of Cardiovascular Medicine

Purpose: Acute undifferentiated febrile illness (AUFI) is a great challenge and burdenin the tropics with respect to diagnosis and clinical practice.Patients presenting with fever alone in Covid-19positive cases is very difficult to distinguish them from other AUFIs in the tropics like Malaria, Scrub Typhus, Dengue and Typhoid. Rapid sero-diagnostic tests of these infectionshad frequently shown sero-positivity for two or more infections leading to difficulty in clinical diagnosis and treatment in endemic zones. This study was performed to determine the false-positive serological test in Covid-19 patients for Typhoid Materials and Methods: The present study was observational prospective study conducted from April 2020 to November 2020. A total of 574 febrile patients which were positive in Real time PCR for Covid-19, were included in the study. Results: Widal test was found positive in 263samples (45.8%). Conclusion: Our experience suggests that cross reactivity in the serological test should be interpreted with caution andcontinuous follow-up of these patients along with surveillance should be done during Covid-19 pandemic in the resource-constrained tropical settings