European Journal of Cardiovascular Medicine

Introduction: Type 2 Diabetes mellitus is the most common metabolic disorder in India. It is assuming epidemic proportions with the Asian-Indian phenotype being more susceptible for the development of the disease. Among Indians, the onset of type 2 diabetes occurs at a younger age making them more vulnerable to develop all the complications of diabetes due to longer duration of the disease. Aims: To study the utility of serum Cystatin C as a marker for early detection of renal dysfunction in type 2 Diabetes Mellitus. Materials and Methods: The study included 50 diabetic patients admitted to/ treated on outpatient basis at the Patna Medical College and Hospitals, Patna during the study period extending from May 2021- April 2023. Result: Glycemic control was assessed by HbA1c. 14 patients (28%) had HbA1c <7% indicating adequate control and 36 (82%) had poorly controlled sugars and 41 patients (82%) all of whom had normal serum creatinine values were found to have 24 hr urine creatinine clearance < 90 mL/min indicating renal dysfunction. Conclusion: Serum Cystatin C appears to hold promise in predicting early renal dysfunction and more so as an indicator of overt nephropathy. The equation of Rule et al seemed to perform better than Grubb’s equation in our study population in estimating GFR.