European Journal of Cardiovascular Medicine

Introduction: Parkinson‟s Disease has been known in India since ancient times. Parkinson‟s Disease is a progressive neurodegenerative disorder characterized by clinical features of bradykinesia, tremor and rigidity. Nearly all forms of PD results from a reduction of Dopaminergic transmission within the Basal ganglia. Aims: To study clinically around 50 patients of Idiopathic Parkinson‟s Disease having non- motor manifestations in and around Patna, Bihar, having a mixed population and the clinical correlation, if any, between non-motor symptoms with that of the severity of Parkinson‟s Disease in accordance with the stages 1 to 5 of the Modified Hoehn and Yahr Scale. Materials and method: This present study was Cross-sectional type of observational study. This study was conducted from April 2021 to October 2022of Patna Medical College and Hospital, Patna. Total 50 patients were included in this study. Result: Majority of the patients (58%), suffer from depression, followed by dementia (30%), followed by hallucination/illusion/ delusion (24%), followed by panic attacks (18%).Percentage of depression was found to be highest in Stage 4 with 71.4% (5 out of 7), followed by Stage 5 (66.67%), Stage 2.5 (57.14%), stage 3 (54.54%), stage 2 stage 1.5 (40%) and stage 1 with (28.57%).The percentage of patients with RBD was highest in Stage 1.5 with 60% (3 out of 5), followed by Stage 3 (45.45), stage 5 (33.33%) and stage 2.5 (28.57%) followed by stage 1 (14.28%) and 4 (14.28%).The percentage of patients with RLS was highest in Stage 2 with 40% (4 out of 10), followed by Stage 5 with 33.3%.The percentage of patients with EDS was highest in Stage 1.5 with 100%, followed by Stage 5 with 66.7%.The percentage of patients with Nocturia was highest in Stage 5 with 100%, followed by Stage 3 with 72.7%. Conclusion: This study helps in screening patients with Parkinson‟s disease (PD) of non- motor symptoms (NMS) and aims at providing holistic treatment improving the quality of life. There is a need for large and well-designed prospective, adequately powered, large community-based study on the prevalence, the symptom, the efficacy of treatment, and the progression over time, of NMS in PD. This will provide a basis for improving the quality of care of these patients by clinicians.