European Journal of Cardiovascular Medicine

Introduction: Gallstones are a major cause of morbidity throughout the world, necessitating hospitalization and cholecystectomy. Gallbladder is known to play crucial role in the formation of gallstones. Therefore, understanding the interaction between gallbladder mucosa and bile is an important step towards understanding the pathogenesis of gallstone disease. Aims: Qualitative and quantitative assessment of gallbladder mucins in chronic calculous cholecystitis and Correlating the mucin histochemistry and morphology of gall bladder in chroniccal culouschole cystitis with each otherand with the chemical composition of gallstones Materials and methods: The present study was a Prospective, Observational institutional based study. This Study was conducted for the duration of 18 monthsat DarbhangaMedical College and Hospital, Laheriasarai, Darbhanga.Total110 patients were included in this study. Result: In the present study, pigment stones were found more often in association with severe inflammation, gastric metaplasia and increased expression of sialomucins,as against cholesterol stones. Conclusion:The normal gallbladder epithelium contains sulphated acid mucins with traces of neutral and sialomucins .The sulphomucin content decreases in chronic calculus cholecystitis