European Journal of Cardiovascular Medicine

Background: Pregnancy induced hypertension also known as Preeclampsia clinically is one of the commonly seen complications in pregnant women. It contributes to the cause of maternal and peri natal morbidity and mortality. According to some study, serum creatinine, Blood urea, serum uric acid level increases during pregnancy induced hypertension. Preeclampsia is associated with renal function impairment. The objective of this study is to compare serum creatinine, Blood Urea and Serum Uric acid in preeclampsia with normal pregnancy. Materials and methods: This are a prospective study carried out in Department of Biochemistry, Tertiary care Teaching Hospital. Pregnant women with gestational age above 32 weeks, attending the antenatal clinic for regular checkups in department of obstetrics were enrolled in this study. The study populations were divided into 2 groups, 90 women has PE, and 90 normotensive pregnant women (NP) were considered as controls. All the participants were age matched. PE were defined according to the International Society for the Study of Hypertension in Pregnancy (ISSHP). PE is GH with proteinuria – 1+ on dipstick or ≥300 mg/day or Pr:Cr ratio as ≥3.0 mg/g. Result: The result showed significantly high blood pressure in Normal pregnant versus PIH (SBP139.33 ± 10.72 VS 199.25 ± 23.9, DBP 101.4 ± 8.33 VS 126.41 ± 11.45) and Blood urea (43.35 ± 11.33 mg% VS 44.38 ± 9.88 mg%), serum creatinine (1.09±0.43 mg/dl mg% VS 1.49±0.23 mg/dl mg%), serum uric acid level (5.39±1.9 mg% VS 7.93 ± 0.22 mg%) in pregnancy induced hypertensive women compares to normal pregnant women. In the present study, in pre-eclampsia, there is elevation of serum uric acid and serum creatinine elevated values are statistically significant. Conclusion: Present study show that uric acid is one of the most studied laboratory tests for the investigation of pre-eclampsia. Not only hyperuricaemia is one of the most reliable indicators for the diagnosis of pre eclampsia. Serum concentrations also are good indicator of severity of the disease.