European Journal of Cardiovascular Medicine

Gestational trophoblastic neoplasia (GTN) is a rare disease that requires prompt diagnosis for successful management and fertility preservation. This case report aims to present a unique case of GTN with brain metastasis. The study was conducted at RD Gardi Medical College in Ujjain, India, in December 2020. A 22-year-old woman presented with symptoms including headaches, low-grade fever, altered sensorium, and right-sided weakness following a two-month history of amenorrhea. A urine pregnancy test confirmed her pregnancy with a single intrauterine embryo, but an ultrasound examination revealed no cardiac activity. Further investigation through a CT brain scan demonstrated mild hydrocephalus, cerebral edema, and elevated CSF beta hCG hormone levels. The initial measurement of β-hCG level was 192,450 mIU/ml, and subsequent serial estimations showed a progressive increase, leading to the diagnosis of GTN with metastatic brain lesions. The patient underwent treatment with methotrexate, a commonly used chemotherapy drug for GTN, alongside supportive therapy. This case report highlights the rarity of GTN with brain metastasis and underscores the importance of an immediate multidisciplinary approach for comprehensive patient assessment and management. Such an approach ensures the best possible outcomes for patients with this condition.