European Journal of Cardiovascular Medicine

Aim: The aim was to study the role of inflammatory markers (IL-6, TNF alpha and C-reactive protein) as prognostic indicator in acute pancreatitis. Method:The study included 76 patients who were admitted in tertiary centre in New Delhi diagnosed as acute pancreatitis for the first time as per Revised Atlanta Classification.Blood samples for inflammatory markers (IL-6,TNF-alpha and C-reactive protein) were sent within 72 hrs of symptoms for evaluation .Later its values were correlated with CECT abdomen  on 3rd and 10 th day. Results : In this  study ,the age of patients involved in this study were between 18-88 years .male predominance was seen in this study(68.4%).The mean C-reactive protein ,TNF-alpha and IL-6 were 145.54,158.47 and 183.44.Modified CT severity score of patients on day 3 was 6(43.4%)where as on day 10 Modified CT severity score was 4 (61.8%).There was a positive significant correlation between Modified CT severity score on day 3 with CRP , TNF- alpha and IL-6. Conclusions: Elevated levels of TNF alpha ,IL-6 and CRP on day 3 are good indicators for  predicting the severity and prognosis of diseases such as acute pancreatitis ,as in our  study it was found that there is a definite correlation between elevated inflammatory  markers and the severity of inflammation of the pancreas.